Quick Publishing

Pathology of the Mouse

edited by: Robert Maronpot
associate editors: Gary Boorman & Beth Gaul

The mouse is an up-and-coming research animal and is heavily utilized in toxicological testing. The mouse is the least costly of the rodents and the relative ease with which transgenic research can be conducted makes it a desirable animal model. An outstanding team of pathologists, headed by Dr. Robert Maronpot at the National Institute of Environmental Heath Sciences, provides a comprehensive survey of mouse pathology. This book is both a reference and atlas in that it covers all systems of the body and is heavily illustrated. Pathology of the Mouse is an indispensable reference for pathologists and biomedical scientists. Each pathologist should have a copy within arm's reach!

Pathology of the Mouse features:

Comprehensive and authoritative
26 peer reviewed chapters
Over 1000 illustrations
Glossy paper
Over 700 pages
Hard-bound
Mechanistically oriented
Published in 1999

700+ pages - ISBN 1-889899-02-X - $199.50

	Editorial Board	viii
	Contributors	ix
	Preface	xi
	Acknowledgements	xi
1	History of the B6C3F1 Mouse - Ghanta N. Rao & Gary A. Boorman	1
	Introduction	1
	History of the Parental Strains	1
	Characteristics of B6C3F1 Hybrid and its Parental Strains	3
	Justification for the Use of the B6C3F1 Hybrid in Chemical Carcinogenicity Studies	4
	Carcinogen Susceptibility of the B6C3F1 Hybrid Mouse	5
2.	Growth, Body Weight Patterns and Life Span of the B6C3F1 Mouse - Ghanta N. Rao	7
	Introduction	7
	Animals, Husbandry, and Observations	7
	Growth and Body Weight Patterns	8
	Mortality Patterns	9
	Discussion	10
	Acknowledgements	11
3.	The Teeth - Philip H. Long & Joel R Leininger	13
	Introduction	13
	Normal Teeth	13
	Congenital Lesions	17
	Degenerative Lesions	17
	Inflammatory and Vascular Lesions	19
	Hyperplastic and Neoplastic Lesions	20
	Miscellaneous Lesions	25
	Toxicologic Lesions	27
	Acknowledgments	27
4.	Oral Cavity, Esophagus and Stomach - Joel R. Leininger, Micheal P. Jokinen, Charles A. Dangler & Laurence O. Whiteley	29
	Introduction	29
	Normal Upper Digestive Tract	29
	Congenital Lesions	33
	Degenerative Lesions	34
	Inflammatory and Vascular Lesions	36
	Hyperplastic and Neoplastic Lesions	38
	Miscellaneous Lesions	45
	Toxicologic Lesions	45
5.	Salivary, Harderian and Lacrimal Glands - Suzanne Botts, MMicheal Jokinen, Elias T. Gaillard, Micheal R. Elwell & Peter C. Mann	49
	Introduction	49
	Normal Salivary Glands	49
	Congenital Lesions of the Salivary Glands	54
	Degenerative Lesions of the Salivary Glands	54
	Inflammatory and Vascular Lesions of the Salivary Glands	55
	Hyperplastic and Neoplastic Lesions of the Salivary Glands	56
	Toxicologic Lesions of the Salivary Glands	62
	Normal Harderian Gland	62
	Degenerative Lesions of the Harderian Gland	63
	Inflammatory Lesions of the Harderian Gland	63
	Hyperplastic and Neoplastic Lesions of the Harderian Gland	63
	Toxicologic Lesions of the Harderian Gland	70
	Mechanistic Studies of the Harderian Gland	71
	Normal Lacrimal Glands	71
	Degenerative Lesions of the Lacrimal Glands	73
	Congenital Lesions of the Lacrimal Glands	73
	Inflammatory Lesions of the Lacrimal Glands	74
	Hyperplastic and Neoplastic Lesions of the Lacrimal Glands	74
	Toxicologic lesions of the Lacrimal Glands	77
6.	Small and Large Intestine, and Mesentery - Cynthia C. Shackelford & Michael R. Elwell	81
	Introduction	81
	Normal Intestine	81
	Congenital Lesions	89
	Degenerative Lesions	90
	Inflammatory and Vascular Lesions	93
	Hyperplastic and Neoplastic Lesions	99
	Miscellaneous Lesions	111
	Toxicologic Lesions	112
7.	Liver and Gallbladder - T. Harada, A. Enomoto, G. A. Boorman & R. R. Maronpot	119
	Introduction	119
	Normal Liver and Gallbladder	120
	Congenital Lesions	126
	Degenerative Lesions	126
	Inflammatory and Vascular Lesions	137
	Hyperplastic and Neoplastic Lesions	140
	Miscellaneous Non-neoplastic Liver and Gallbladder Lesions	163
	Toxicologic Lesions	167
	Mechanistic Studies with the Liver	171
8.	Exocrine and Endocrine Pancreas - Gary A. Boorman & Robert C. Sills	185
	Introduction	185
	Normal Exocrine and Endocrine Pancreas	185
	Congenital Lesions	190
	Degenerative Lesions	190
	Inflammatory and Vascular Lesions	193
	Hyperplastic and Neoplastic Lesions	194
	Miscellaneous Lesions	201
	Toxicological Lesions	202
9.	Kidney - John Curtis Seely	207
	Introduction	207
	Normal Kidney	207
	Congenital Lesions	211
	Degenerative Lesions	212
	Inflammatory and Vascular Lesions	215
	Hyperplastic and Neoplastic Lesions	217
	Toxicologic Lesions	226
10.	Ureter, Urinary Bladder, and Urethra - Elias T. Gaillard	235
	Introduction	235
	Normal Urinary Pathway	235
	Congenital Lesions	241
	Inflammatory and Vascular Lesions	241
	Hyperplastic and Neoplastic Lesions	241
	Miscellaneous Lesions	251
	Toxicologic Lesions	254
11.	Nose, Larynx, and Trachea - Ronald A. Herbert & Joel R. Leininger	259
	Introduction	259
	Embryology	259
	Normal Upper Respiratory Tract	260
	Physiology	273
	Congenital Lesions	274
	Inflammatory and Vascular Lesions	274
	Degenerative and Regenerative Lesions	275
	Hyperplastic and Neoplastic Lesions	281
	Miscellaneous Lesions	288
	Toxicologic Lesions	289
12.	Lungs, Pleura, and Mediastinum - Darlene Dixon, Ronald A. Herbert, Robert C. Sills & Gary A. Boorman	293
	Introduction	293
	Normal Lung, Pleura, and Mediastinum	294
	Congenital Lesions - Lung	300
	Inflammatory and Vascular Lesions - Lung	300
	Hyperplastic Lesions	302
	Neoplastic Lesions	305
	Miscellaneous Lesions	318
	Toxicologic Lesions	320
	Molecular Biology of Lung Tumors in Mice	323
13.	Thymus, Spleen, and Lymph Nodes - Jerrold M. Ward, Peter C. Mann, Hideki Morishima & Charles H. Frith	333
	Thymus
	Normal Thymus	333
	Congenital Lesions	334
	Disturbances of Growth	335
	Degenerative Lesions	335
	Inflammatory and Vascular Lesions	336
	Hyperplastic Lesions	336
	Neoplastic Lesions	337
	Toxicologic Lesions	337
	Spleen
	Normal Spleen	339
	Congenital Lesions	340
	Degenerative Lesions	340
	Inflammatory and Vascular Lesions	342
	Hyperplastic Lesions	342
	Neoplastic Lesions	344
	Toxicologic Lesions	352
	Lymph Nodes
	Normal Lymph Nodes	354
	Congenital Lesions	354
	Degenerative Lesions	354
	Inflammatory and Vascular Lesions	356
	Hyperplastic Lesions	356
	Neoplastic Lesions	357
	Toxicologic Lesions	357
14.	Heart, Blood and Lymphatic Vessels - Michael R. Elwell & Joel F. Mahler	361
	Introduction	361
	Normal Heart and Vasculature	361
	Congenital Lesions	364
	Degenerative Lesions	364
	Inflammatory Lesions	370
	Hyperplastic and Neoplastic Lesions	372
	Toxicologic Lesions	375
15.	The Male Reproductive Tract - Ann Radovsky, Kunitoshi Mitsumori & Robert C. Chapin	381
	Introduction	381
	Embryology	381
	Anatomy, Histology and Physiology	382
	Congenital Lesions	389
	Degenerative Lesions	391
	Inflammatory and Vascular Lesions	393
	Hyperplastic and Neoplastic Lesions	394
	Toxicologic Techniques and Lesions	401
	Transgenic Models	405
16.	Ovary, Oviduct, Uterus, Cervix and Vagina - Barbara J. Davis, Darlene Dixon & Ronald A. Herbert	409
	Introduction	409
	Ovary	409
	Oviduct	430
	Uterus	431
	Cervix and Vagina	440
17.	The Nervous System - Ann Radovsky & Joel F. Mahler	445
	Introduction	445
	Techniques	445
	Embryology	448
	Anatomy and Histology	449
	Histopathology of the Nervous System	452
	Developmental Lesions	453
	Degenerative and Aging Lesions	454
	Inflammatory and Vascular Lesions	456
	Neoplasms	457
	Toxicologic Lesions	465
	Mechanistic Studies	468
18.	The Eyes - Volker Geiss & Katsuhiko Yoshitomi	471
	Introduction	471
	Normal	471
	Congenital Lesions	475
	Degenerative and Dystrophic Lesions	476
	Inflammatory and Vascular Lesions	480
	Hyperplastic and Neoplastic Lesions	482
	Miscellaneous Lesions	485
	Toxicological Lesions	485
19.	The Pituitary Gland - Joel F. Mahler & Michael R. Elwell	491
	Introduction	491
	Normal Pituitary Gland	491
	Congenital Lesions	495
	Degenerative Lesions	495
	Inflammatory and Vascular Lesions	496
	Proliferative Lesions	497
	Miscellaneous Lesions	503
	Toxicologic Lesions	504
	Mechanistic Studies of Pituitary Tumorigenesis in Mice	505
20.	The Adrenal Gland - Abraham Nyska & Robert R. Maronpot	509
	Introduction	509
	Normal Adrenal Gland	509
	Congenital Lesions	513
	Degenerative Lesions	514
	Inflammatory and Vascular Lesions	516
	Hyperplastic, Hypertrophic, and Neoplastic Lesions	517
	Neoplasms Metastatic to the the Adrenal	528
	Experimental and Toxicologic Lesions	529
	Mechanistic Studies with the Adrenal Glands	532
21.	The Thyroid and Parathyroid Glands - Jerry F. Hardisty & Gary A. Boorman	537
	Introduction	537
	Normal Thyroid and Parathyroid Gland	537
	Congenital Lesions	543
	Degenerative Lesions	545
	Inflammatory and Vascular Lesions	545
	Hyperplastic and Neoplastic Lesions	546
	Miscellaneous Lesions	552
	Toxicologic Lesions	552
22.	Skin and Subcutis - John C. Peckham & Katharina Heider	555
	Introduction	555
	Normal Skin and Subcutis	556
	Congenital Lesions	562
	Degenerative Lesions	562
	Inflammatory and Vascular Lesions	565
	Hyperplasia and Neoplastic Lesions	569
	Miscellaneous Lesions	604
	Toxicologic and Experimental Lesions	604
23.	Mammary Gland and Specialized Sebaceous Glands (Zymbal, Preputial, Clitoral, Anal) - John Curtis Seely & Gary A. Boorman	613
	Introduction	613
	Normal Development and Anatomy Mammary Gland	613
	Congenital Lesions - Mammary Gland	615
	Degenerative Lesions - Mammary Gland	615
	Inflammatory and Vascular Lesions - Mammary Gland	615
	Hyperplastic and Neoplastic Lesions - Mammary Gland	616
	Toxicologic Lesions - Mammary Gland	623
	Normal Development and Anatomy - Specialized Sebaceous Gland	623
	Congenital Lesions - Specialized Sebaceous Gland	625
	Degenerative Lesions - Specialized Sebaceous Gland	626
	Inflammatory and Vascular Lesions - Specialized Sebaceous Gland	628
	Hyperplastic and Neoplastic Lesions - Specialized Sebaceous Gland	628
	Toxicologic Lesions - Specialized Sebaceous Gland	632
24.	Skeletal Muscle - Joel R. Leininger	637
	Introduction	637
	Normal Skeletal Muscle	637
	Congenital Lesions	638
	Degenerative Lesions	639
	Inflammatory and Vascular Lesions	639
	Hyperplastic and Neoplastic Lesions	640
	Miscellaneous Lesions	641
	Toxicologic Lesions	642
25.	Bones, Joints, and Synovia - Philip H. Long & Joel R. Leininger	645
	Introduction	645
	Normal Bones, Joints, and Synovia	645
	Congenital Lesions	652
	Degenerative Lesions	652
	Inflammatory and Vascular Lesions	659
	Hyperplastic and Neoplastic Lesions	662
	Miscellaneous Lesions	672
	Toxicologic Lesions	673
26.	Neoplasm Incidences in B6C3F1 Mice: NTP Historical Data - Joseph K. Haseman, Michael R. Elwell & James R. Hailey	679
	Index	691

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Pathology of the Mouse features: Comprehensive and authoritative 26 peer reviewed chapters Over 1000 illustrations Glossy paper Over 700 pages Hard-bound Mechanistically oriented Published in 1999

Pathology of the Mouse features:

Table of Contents

Pathology of the Mouse features:

Comprehensive and authoritative
26 peer reviewed chapters
Over 1000 illustrations
Glossy paper
Over 700 pages
Hard-bound
Mechanistically oriented
Published in 1999